Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation, and Thrombus Stability
نویسندگان
چکیده
منابع مشابه
Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation, and Thrombus Stability*
Platelet secretion not only drives thrombosis and hemostasis, but also mediates a variety of other physiological and pathological processes. The ubiquitous SNARE machinery and a number of accessory proteins have been implicated in regulating secretion in platelet. Although several platelet SNAREs have been identified, further members of the SNARE family may be needed to fine-tune platelet secre...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY The actin cytoskeleton differentially regulates platelet -granule and dense-granule secretion
Stimulation of platelets with strong agonists results in centralization of cytoplasmic organelles and secretion of granules. These observations have led to the supposition that cytoskeletal contraction facilitates granule release by promoting the interaction of granules with one another and with membranes of the open canalicular system. Yet, the influence of the actin cytoskeleton in controllin...
متن کاملThe actin cytoskeleton differentially regulates platelet -granule and dense-granule secretion
http://bloodjournal.hematologylibrary.org/content/105/10/3879.full.html Updated information and services can be found at: (1930 articles) Signal Transduction (2497 articles) Hemostasis, Thrombosis, and Vascular Biology (143 articles) Cytoskeleton Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#r...
متن کاملHeat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation.
Molecular chaperones that support protein quality control, including heat shock protein 70 (Hsp70), participate in diverse aspects of cellular and physiological function. Recent studies have reported roles for specific chaperone activities in blood platelets in maintaining hemostasis; however, the functions of Hsp70 in platelet physiology remain uninvestigated. Here we characterize roles for Hs...
متن کاملIntercellular calcium communication regulates platelet aggregation and thrombus growth
The ability of platelets to form stable adhesion contacts with other activated platelets (platelet cohesion or aggregation) at sites of vascular injury is essential for hemostasis and thrombosis. In this study, we have examined the mechanisms regulating cytosolic calcium flux during the development of platelet-platelet adhesion contacts under the influence of flow. An examination of platelet ca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m114.602615